Cell Signaling Dlst Antibody

Name: Cell Signaling Dlst Antibody
SKU: CSIG-5556S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Dlst Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-5556S

MFG.PART: 5556S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	50
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	DLST Antibody detects endogenous levels of total DLST protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro188 of human DLST protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	α-ketoglutarate dehydrogenase complex is a rate-regulating enzyme in the Krebs Cycle (1). Dihydrolipoamide succinyltransferase (DLST) is a key subunit in this complex (2). Reduction of DLST increases reactive oxygen species production, suggesting its role in oxidative stress (2). Research has shown that deficiency of DLST in mice is linked to increased oxidative stress in mitochondria, a process that may be involved in the pathogenesis of Alzheimers disease (2).

Specifications