Cell Signaling Nrcam Antibody

Name: Cell Signaling Nrcam Antibody
SKU: CSIG-55284S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Nrcam Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-55284S

MFG.PART: 55284S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	140
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody
Specificity/Sensitivity	NRCAM Antibody recognizes endogenous levels of NRCAM protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NRCAM protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Neuronal Cell Adhesion Molecule, or NRCAM, belongs to the immunoglobulins Cell Adhesion Molecules (CAMs) superfamily (1). NRCAM, an ankyrin-binding protein, contributes to the neurite outgrowth by providing directional signaling during axonal cone growth (2, 3, 4). Additionally, it plays a role in mediating the interaction between axons and Schwann cells and contributes to the formation and maintenance of Nodes of Ranvier (5, 6, 7, 8). NRCAM also plays an important role in the establishment of dendritic spines in developing cortical neurons (9). NRCAM is expressed in non-neuronal cells, mostly in endothelial cells (10).

Specifications