Cell Signaling Il-18 (D2f3b) Rabbit mAb

Name: Cell Signaling Il-18 (D2f3b) Rabbit mAb
SKU: CSIG-54943S
Price: 362.59 USD

List Price $362.59 Your Price $362.59

Cell Signaling Il-18 (D2f3b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54943S

MFG.PART: 54943S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	22
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	IL-18 (D2F3B) Rabbit mAb recognizes endogenous levels of total IL-18 protein. This antibody detects 110 and 250 kDa bands of unknown origin in some cell lines.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human IL-18 recombinant protein.
Background	Interleukin-18 (IL-18), originally known as interferon-gamma inducing factor (IGIF), is part of the IL-superfamily of cytokines (1,2). This proinflammatory cytokine is synthesized as an inactive precursor which requires cleavage by Caspase-1 to become an active, mature molecule, which is secreted by monocytes and macrophages (3,4,6). It induces IFNγ production in T-helper-1 (Th1) cells and natural killer (NK) cells, and can regulate innate immunity via both Th1 and Th2 responses (4,5). Elevated IL-18 levels are associated with autoimmune disease, but may be balanced by binding to IL-18 binding protein (IL-18BP), which along with IL-18 neutralizing antibodies, are being examined in clinical trials (6,7).

Specifications