Cell Signaling Dog1/Anoctamin 1 (K9) Mouse mAb

Name: Cell Signaling Dog1/Anoctamin 1 (K9) Mouse mAb
SKU: CSIG-54598S
Price: 353.50 USD

List Price $353.50 Your Price $353.50

Cell Signaling Dog1/Anoctamin 1 (K9) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54598S

MFG.PART: 54598S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG2b
Application/Dilution	{IHC Leica Bond: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	DOG1/Anoctamin 1 (K9) Mouse mAb recognizes endogenous levels of DOG1/Anoctamin 1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to the carboxy terminus of human DOG1/Anoctamin 1 protein.
Background	Anoctamin 1, also called DOG1 for discovered on gastrointestinal stromal tumors protein 1 or TMEM16A for Transmembrane Member 16A, is a plasma membrane calcium-activated chloride channel (1). It is essential for chloride secretion from epithelial tissues (2), and has been shown to be a specific marker for cells of Cajal (3), the pacemaker cells that control smooth muscle contraction. Anoctamin 1 knockout mice exhibit an altered gastric smooth muscle rhythmic contraction (4). More recently, research studies have identified Anoctamin 1 as a heat sensor in nociceptive neurons (5). Heat above 44ºC triggers anoctamin 1-dependent depolarization, contributing to the mediation of thermal nociception (5).

Specifications