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Cell Signaling Map1s Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Map1s Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-54232S
MFG.PART:
54232S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 125, 142 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | MAP1S Antibody recognizes endogenous levels of total MAP1S protein. |
| Species Reactivity | Mouse, Rat |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg499 of mouse MAP1S protein. Antibodies are purified by peptide affinity chromatography. |
| Background | MAP1S is a member of the microtubule-associated protein (MAP) family. There are at least ten proteins in the MAP family, including MAP1A, MAP1B, MAP1S, MAP2, MAP6, MAP7, MAP9, Tau, DCLK, and DCX. MAP1 subfamily members express predominantly in brain cells regulating several physiological processes in cells, including cytoskeleton regulation that, in some cases are energy-dependent, including the autophosphorylation and phosphorylation of other MAP family members, and other cytoskeletal proteins (1,2). MAP1 family members have been identified as high-molecular-weight proteins consisting of the full-length (FL), at least one heavy chain (HC), one light chain (LC), and, in some members short chains (SC) (2,3). The FL-MAP1S is formed by the HC and LC, forming the active MAP1S complex. The LC binds, bundles, and stabilizes microtubules, and the HC regulates LC activity (2). MAP1S also interacts with Nemitin (neuronal enriched MAP interacting protein), enhancing cytoskeleton regulation (4).MAP1S contributes to mitochondria stabilization by interacting with mitochondrion-associated leucine-rich PPR-motif containing protein (LRPPRC). MAP1S regulates ubiquitination processes like autophagosome biogenesis and protein clearance. These processes are MAP1S isoform-specific (5). An increased level of MAP1S enhances autophagy to remove p62-associated aggresomes and dysfunctional organelles that trigger DNA double-strand breaks and genome instability (6). |
| SKU | CSIG-54232S |
|---|---|
| Featured | No |
| Supplier Part Number | 54232S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |