Cell Signaling Perilipin-1 (D1d8) Xp Rabbit mAb (Alexa Fluor 647 Conjugate)

Name: Cell Signaling Perilipin-1 (D1d8) Xp Rabbit mAb (Alexa Fluor 647 Conjugate)
SKU: CSIG-52975S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Perilipin-1 (D1d8) Xp Rabbit mAb (Alexa Fluor 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-52975S

MFG.PART: 52975S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Frozen): 1:50 - 1:200, Immunofluorescence (Immunocytochemistry): 1:50 - 1:200}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Perilipin-1 (D1D8) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) detects endogenous levels of total perilipin-1 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues around Ile419 of human perilipin-1 protein.
Background	Triacylglycerol is stored in lipid droplets as a primary energy reserve. Perilipin is localized at the periphery of lipid droplets and serves as a protective coating against lipases (1-3). Evidence suggests that PKA regulates lipolysis by phosphorylating perilipin (1,2,4,5). Phosphorylation of perilipin results in the conformational change that exposes lipid droplets to endogenous lipases, such as hormone-sensitive lipases (2). Hence, perilipin plays a pivotal role in lipid storage (2,5).

Specifications