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Cell Signaling Srpk1 (E7j5u) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Srpk1 (E7j5u) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-52012S
MFG.PART:
52012S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 100 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SRPK1 (E7J5U) Rabbit mAb recognizes endogenous levels of total SRPK1 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys377 of human SRPK1 protein. |
| Background | Serine/arginine-rich protein-specific kinases (SRPKs) constitute a small family of serine/threonine protein kinases that phosphorylate serine residues in sequence regions containing repetitive serine/arginine-rich dipeptides (SR domains) (1). There are three known family members (SRPK1-3), of which SRPK1 and SRPK2 are the most well-studied. Multiple research studies have shown these kinases play important roles in post-transcriptional regulation, notably via phosphorylation of SR-family RNA splicing factors (2). Early studies of SRPK proteins in mice suggested that SRPK1 was expressed ubiquitously, whereas SRPK2 exhibited more tissue-specific expression patterns, while demonstrating conserved substrate specificity (3). SRPK2 has since been implicated in lipid biogenesis, following activation through sequential phosphorylation by mTORC-activated S6K1 and casein kinase 1 (5). Phosphorylation of SRPK2 at Ser494 and Ser497 promotes nuclear translocation of SRPK2, thereby enabling its regulation of mRNA splicing factors involved in lipid biogenesis. Notably, SRPK1 and SRPK2 have both been implicated in the phosphorylation of key viral proteins (5), including the nucleocapsid protein of the SARS and SARS-CoV-2 coronaviruses (6), a modification that may be essential for viral replication. |
| SKU | CSIG-52012S |
|---|---|
| Featured | No |
| Supplier Part Number | 52012S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |