Cell Signaling Rbm4 Antibody

Name: Cell Signaling Rbm4 Antibody
SKU: CSIG-50703S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Rbm4 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-50703S

MFG.PART: 50703S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	41
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	RBM4 Antibody recognizes endogenous levels of total RBM4 protein. This antibody also detects RBM4B protein.
Species Reactivity	Human, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro317 of human RBM4 protein. Antibodies are purified by peptide affinity chromatography.
Background	RBM4 functions as an RNA-binding protein and precursor mRNA splicing factor that antagonizes activity of PTBP1-mediated splicing (1-4). Upon phosphorylation at Ser309, RBM4 accumulates in stress granules and suppresses cap-dependent translation through eIF4A (3). Exon skipping of MEF2C by RBM4 has been shown to play a key role in the differentiation of brown adipocytes (5). The splicing activities of RBM4 seem to suppress tumorigenesis in the context of multiple cancer types (5-8).

Specifications