Cell Signaling Angiopoietin-2 (D200) Antibody

Name: Cell Signaling Angiopoietin-2 (D200) Antibody
SKU: CSIG-50697S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Angiopoietin-2 (D200) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-50697S

MFG.PART: 50697S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	68, 70
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Angiopoietin-2 (D200) Antibody recognizes endogenous levels of total angiopoietin-2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp200 of human angiopoietin-2 protein. Antibodies are purified by peptide affinity chromatography.
Background	Angiopoietins are a family of Tie receptor ligands. There are four angiopoietins discovered so far: angiopoietins 1, 2, 3 and 4 (Ang1, 2, 3, and 4) (1-3). Ang1 binds to the Tie-2 receptor and leads to its autophosphorylation and subsequent activation of downstream signaling pathways. It plays an important role in blood vessel formation, maturation and subsequent stabilization (1,4,5). Ang2 is an endothelium-specific growth factor that functions as an antagonist to Ang1, promotes vascular associated proinflammatory function, destabilizes quiescent endothelium, leads to vascular leakage and vascular destabilization and remodeling (2,6,7). Ang2 is selectively expressed in many tumor tissues where, combined with other growth factors such as VEGF, it can promote vascular remodeling, angiogenesis and inflammation (7-9).

Specifications