Cell Signaling Ho-1 (P249) Antibody

Name: Cell Signaling Ho-1 (P249) Antibody
SKU: CSIG-5061S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Ho-1 (P249) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-5061S

MFG.PART: 5061S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	28
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	HO-1 (P249) Antibody detects endogenous levels of total HO-1 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acid residues surrounding Pro249 of human HO-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme that results in the release of carbon monoxide, iron, and biliverdin (1). The products of this enzymatic reaction play important biological roles in antioxidant, anti-inflammatory, and cytoprotective functions (2). HO comprises two isozymes, including the constitutively expressed HO-2 isozyme and the inducible HO-1 isozyme (3). Inducible HO-1 is expressed as an adaptive response to several stimuli, including heme, metals, and hormones (4). The induction of HO-1 has been implicated in numerous disease states, such as transplant rejection, hypertension, atherosclerosis, Alzheimers disease, endotoxic shock, diabetes, inflammation, and neurological disorders (1,5).

Specifications