Cell Signaling Granzyme B (D2h2f) Rabbit mAb (Alexa Fluor 647 Conjugate)

Name: Cell Signaling Granzyme B (D2h2f) Rabbit mAb (Alexa Fluor 647 Conjugate)
SKU: CSIG-50590S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Granzyme B (D2h2f) Rabbit mAb (Alexa Fluor 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-50590S

MFG.PART: 50590S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Granzyme B (D2H2F) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total Granzyme B protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human Granzyme B protein.
Background	Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells (1). Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2,3).

Specifications