Cell Signaling S6 Ribosomal Protein (5g10) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling S6 Ribosomal Protein (5g10) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-50570SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling S6 Ribosomal Protein (5g10) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-50570SF

MFG.PART: 50570SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	32
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #2217
Specificity/Sensitivity	S6 Ribosomal Protein (5G10) Rabbit Monoclonal Antibody (BSA and Azide Free) detects endogenous levels of total S6 ribosomal protein independent of phosphorylation.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues of human S6 ribosomal protein.
Background	One way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation (1,2). Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of S6 ribosomal protein. Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5 untranslated regions (2). These particular mRNA transcripts (5TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation (2,3). Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of S6 protein (4,5).

Specifications