Cell Signaling La Antigen (D19b3) Rabbit mAb

Name: Cell Signaling La Antigen (D19b3) Rabbit mAb
SKU: CSIG-5034S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling La Antigen (D19b3) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-5034S

MFG.PART: 5034S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	50
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	La Antigen (D19B3) Rabbit mAb detects endogenous levels of total La Antigen protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu97 of human La Antigen protein.
Background	La antigen is recognized by antibodies in patients with autoimmune disorders such as systemic lupus erythematosus and Sjögrens syndrome (1). La antigen binds to the 5-noncoding region of poliovirus RNA and is an IRES trans-acting factor (1,2). Depletion of La antigen reduces the function of poliovirus IRES in vivo (3). La antigen, when phosphorylated at Ser366, has been shown to associate with nuclear precursor tRNAs and facilitate their processing (4). The nonphosphorylated La antigen interacts with the mRNAs that have 5-terminal oligopyrimidine (5TOP) motifs to control protein synthesis (4).

Specifications