Cell Signaling Ddr1 (D1g6) Xp ® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Ddr1 (D1g6) Xp ® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-49876SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Ddr1 (D1g6) Xp ® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-49876SF

MFG.PART: 49876SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	125
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #5583
Specificity/Sensitivity	DDR1 (D1G6) XP® Rabbit mAb (BSA and Azide Free) detects endogeneous levels of total DDR1 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro600 of human DDR1 protein.
Background	The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2 (1). They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling (2). Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion (1).

Specifications