Cell Signaling Asparagine Synthetase (E6c2c) Xp® Rabbit mAb (Alexa Fluor® 647 Conjugate)

Name: Cell Signaling Asparagine Synthetase (E6c2c) Xp® Rabbit mAb (Alexa Fluor® 647 Conjugate)
SKU: CSIG-49791S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Asparagine Synthetase (E6c2c) Xp® Rabbit mAb (Alexa Fluor® 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-49791S

MFG.PART: 49791S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Asparagine Synthetase (E6C2C) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total asparagine synthetase protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly473 of human asparagine synthetase protein.
Background	Asparagine synthetase (ASNS) catalyzes the synthesis of asparagine from aspartate and glutamine. Research studies have shown that intracellular asparagine can suppress apoptosis in a large number of human tumors. In addition, ASNS expression levels have been associated with the progression of gliomas and neuroblastomas in patients (1). Furthermore, acute lymphocytic leukemia cells frequently depend upon serum asparagine for their viability, as they lack ASNS (2). Deprivation of asparagine by L-asparaginase has therefore been developed as a therapeutic treatment for acute lymphocytic leukemia (2,3). In subsets of gastric and hepatic cancers, ASNS promoter hypermethylation correlates with low ASNS expression, sensitizing these cancers to the asparaginase treatment (4).

Specifications