Cell Signaling Hla-G (E8n9c) Xp® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Hla-G (E8n9c) Xp® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-49508SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Hla-G (E8n9c) Xp® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-49508SF

MFG.PART: 49508SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	30-40
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #79769.
Specificity/Sensitivity	HLA-G (E8N9C) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total HLA-G protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu102 of human HLA-G protein.
Background	HLA-G (HLA-G histocompatibility antigen, class I, G) is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors. Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble (1-4). It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy (1-5). HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte/macrophage cells (4-5). Its involvement in evasion of immune response makes it a potential target for immunotherapy (6).

Specifications