Cell Signaling Hsp60 (D307) Antibody

Name: Cell Signaling Hsp60 (D307) Antibody
SKU: CSIG-4870S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Hsp60 (D307) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4870S

MFG.PART: 4870S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk Dm
Sensitivity	Endogenous
Molecular Weight (kDa)	60
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:50, Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	HSP60 (D307) Antibody detects endogenous levels of total HSP60 protein. This antibody does not cross-react with other HSPs.
Species Reactivity	Human, Mouse, Rat, Monkey, D. melanogaster
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Asp307 of human HSP60. Antibodies are purified by protein A and peptide affinity chromatography.
Background	In both prokaryotic and eukaryotic cells the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones (1-3). HSP60 has primarily been known as a mitochondrial protein that is important for folding key proteins after import into the mitochondria (4). Research studies have shown that a significant amount of HSP60 is also present in the cytosol of many cells, and that it is induced by stress, inflammatory and immune responses, and autoantibodies correlated with Alzheimers, coronary artery diseases, MS, and diabetes (5-8).

Specifications