Cell Signaling 4-1bb/Cd137/Tnfrsf9 (E8t1q) Rabbit mAb

Name: Cell Signaling 4-1bb/Cd137/Tnfrsf9 (E8t1q) Rabbit mAb
SKU: CSIG-47282S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling 4-1bb/Cd137/Tnfrsf9 (E8t1q) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-47282S

MFG.PART: 47282S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	32, 40
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	4-1BB/CD137/TNFRSF9 (E8T1Q) Rabbit mAb recognizes endogenous levels of total 4-1BB/CD137/TNFRSF9 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln128 of human 4-1BB/CD137/TNFRSF9 protein.
Background	TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).

Specifications