Cell Signaling Dkk2 (N70) Antibody

Name: Cell Signaling Dkk2 (N70) Antibody
SKU: CSIG-4689S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Dkk2 (N70) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4689S

MFG.PART: 4689S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Transfected Only
Molecular Weight (kDa)	28, 32
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	DKK2 (N70) Antibody detects transfected levels of human DKK2 protein. This antibody does not cross-react with DKK1.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn70 of human DKK2. Antibodies are purified by peptide affinity chromatography.
Background	Dickkopf (DKK) family proteins consist of four members DKK1, DKK2, DKK3 and DKK4 that function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5 and LRP6 (1,2). DKKs contain two cysteine-rich domains in which the positions of 10 cysteine residues are well conserved (3). Their expression is both temporally and spatially regulated during animal development (4). DKKs also bind with high affinity to transmembrane proteins Kremen1 and 2, which themselves also modulate Wnt signaling (5,6).DKK2 plays a role in osteoblast terminal differentiation and formation of mineralized matrix and is required for differentiation of non-keratinizing stratified epithelium from the corneal epithelial progenitors (7,8).

Specifications