Cell Signaling Gsk-3beta (3d10) Mouse mAb (Bsa And Azide Free)

Name: Cell Signaling Gsk-3beta (3d10) Mouse mAb (Bsa And Azide Free)
SKU: CSIG-46835SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Gsk-3beta (3d10) Mouse mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-46835SF

MFG.PART: 46835SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Hm Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	46
Source/Isotype	Mouse IgG2a
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #9832
Specificity/Sensitivity	GSK-3β (3D10) Mouse mAb (BSA and Azide Free) recognizes endogenous levels of total GSK-3β protein. This antibody does not cross-react with GSK-3α.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy-terminus of human GSK-3β protein.
Background	Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).

Specifications