Cell Signaling Tle1/2/3/4 Antibody

Name: Cell Signaling Tle1/2/3/4 Antibody
SKU: CSIG-4681S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Tle1/2/3/4 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4681S

MFG.PART: 4681S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M Mk Dm
Sensitivity	Endogenous
Molecular Weight (kDa)	78-90
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TLE1/2/3/4 Antibody detects endogenous levels of TLE1, TLE2, TLE3, and TLE4 proteins. Based on homology it should also recognize TLE1 and TLE2 of Zebra fish, TLE2 of Xenopus, and Groucho of Drosophila.
Species Reactivity	Human, Mouse, Monkey, D. melanogaster
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp760 of human TLE1. Antibodies are purified by peptide affinity chromatography.
Background	Transducin-like enhancer of split proteins (TLE1, TLE2, TLE3, TLE4, and TLE6) are mammalian homologs of Drosophila Groucho (1). TLEs contain several WD-repeats implicated in protein-protein interaction (2,3). TLEs are transcriptional co-repressors that bind to many transcription factors, such as LEF1, Runx1, Oct-1, hepatocyte nuclear factor 3-β as well as histone H3 (4-7). TLEs are differentially expressed during animal development and may have overlapping as well as distinct functions (8).

Specifications