Cell Signaling Alpha-Smooth Muscle Actin (1a4) Mouse mAb (Alexa Fluor 488 Conjugate)

Name: Cell Signaling Alpha-Smooth Muscle Actin (1a4) Mouse mAb (Alexa Fluor 488 Conjugate)
SKU: CSIG-46469S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Alpha-Smooth Muscle Actin (1a4) Mouse mAb (Alexa Fluor 488 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-46469S

MFG.PART: 46469S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Mouse IgG2a
Application/Dilution	{Immunofluorescence (Frozen): 1:50 - 1:200}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	α-Smooth Muscle Actin (1A4) Mouse mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total α-smooth muscle actin protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human α-smooth muscle protein.
Background	Actin proteins are major components of the eukaryotic cytoskeleton. At least six vertebrate actin isoforms have been identified. The cytoplasmic β- and γ-actin proteins are referred to as “non-muscle” actin proteins as they are predominantly expressed in non-muscle cells where they control cell structure and motility (1). The α-cardiac and α-skeletal actin proteins are expressed in striated cardiac and skeletal muscles, respectively. The smooth muscle α-actin and γ-actin proteins are found primarily in vascular smooth muscle and enteric smooth muscle, respectively. The α-smooth muscle actin (ACTA2) is also known as aortic smooth muscle actin. These actin isoforms regulate the contractile potential of muscle cells (1).

Specifications