Cell Signaling C-Peptide Antibody

Name: Cell Signaling C-Peptide Antibody
SKU: CSIG-4593S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling C-Peptide Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4593S

MFG.PART: 4593S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	4
Source/Isotype	Rabbit
Application/Dilution	{Immunohistochemistry (Paraffin): 1:100, Immunofluorescence (Frozen): 1:400, Immunofluorescence (Immunocytochemistry): 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	C-peptide Antibody detects endogenous levels of total C-peptide protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human C-peptide. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Glucose homeostasis is regulated by hormones. Elevation of blood glucose levels during feeding stimulates insulin release from pancreatic β-cells through a glucose sensing pathway (1). Proinsulin, the insulin precursor molecule, is processed prior to its secretion. Insulin is composed of A-peptide and B-peptide which are joined by a disulfide bond. The center one-third of the molecule is cleaved and released as C-peptide, which has a longer half-life than insulin (2).

Specifications