Cell Signaling Dynamin-I (3g4b6) Mouse mAb

Name: Cell Signaling Dynamin-I (3g4b6) Mouse mAb
SKU: CSIG-4565S
Price: 339.36 USD

List Price $339.36 Your Price $339.36

Cell Signaling Dynamin-I (3g4b6) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4565S

MFG.PART: 4565S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Mouse IgG2a
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Dynamin-I (3G4B6) Mouse mAb detects endogenous levels of total dynamin-I protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant carboxy-terminal fragment of human dynamin-I.
Background	Dynamin is a family of large GTPases that has been implicated in the formation of vesicles of both the endocytotic and secretory processes (1). Dynamin plays an important role in the internalization of cell surface receptors, a process that attenuates the response to extracellular signals. It has been illustrated that dynamin interacts with signaling proteins such as Src, PLCγ, PKC and G-proteins. PKC and Src phosphorylate dynamin, and its phosphorylation may regulate the endocytosis of cell surface receptors (2,3).

Specifications