Cell Signaling Cxcl1/Cxcl2 (E5m6d) Rabbit mAb (Biotinylated)

Name: Cell Signaling Cxcl1/Cxcl2 (E5m6d) Rabbit mAb (Biotinylated)
SKU: CSIG-45597S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Cxcl1/Cxcl2 (E5m6d) Rabbit mAb (Biotinylated) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45597S

MFG.PART: 45597S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	9
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 136 mM NaCl, 2.6 mM KCI, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg/ml BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CXCL1/CXCL2 (E5M6D) Rabbit mAb (Biotinylated) recognizes endogenous levels of total CXCL1 and CXCL2 proteins. This antibody is more sensitive for detection of CXCL1 protein than CXCL2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human CXCL1 recombinant protein.
Background	CXCL1 and CXCL2 (GRO-α and GRO-β) are two of the chemokines that act as ligands for the chemokine receptor CXCR2 (1). CXCR2 is expressed by several types of leukocytes and plays an important role in the recruitment of neutrophils to sites of inflammation (2). Although neutrophil recruitment is an important component of the innate immune system’s response to infection or injury, prolonged or excessive neutrophil recruitment can lead to inflammatory disease. Therefore, blocking CXCR2 has been pursued as a therapeutic approach for a variety of inflammatory diseases (3). In addition, CXCL1 and CXCL2 expression can be elevated in the tumor microenvironment, which contributes to tumor cell survival through enhanced angiogenesis and recruitment of immunosuppressive myeloid-derived suppressor cells (MDSCs) (4,5).

Specifications