Cell Signaling Tnfrsf17/Bcma (E6d7b) Rabbit mAb (Pe Conjugate)

Name: Cell Signaling Tnfrsf17/Bcma (E6d7b) Rabbit mAb (Pe Conjugate)
SKU: CSIG-45576S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Tnfrsf17/Bcma (E6d7b) Rabbit mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45576S

MFG.PART: 45576S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	TNFRSF17/BCMA (E6D7B) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total TNFRSF17/BCMA protein. This antibody displays some non-specific staining of peripheral and CNS tissue when used for IHC-P.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17/BCMA protein.
Background	B cell maturation antigen (BCMA/TNFRSF17/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10).

Specifications