Cell Signaling Phospho-Map2 (Thr1620/1623) Antibody

Name: Cell Signaling Phospho-Map2 (Thr1620/1623) Antibody
SKU: CSIG-4544S
Price: 360.57 USD

List Price $360.57 Your Price $360.57

Cell Signaling Phospho-Map2 (Thr1620/1623) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4544S

MFG.PART: 4544S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	82, 280
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-MAP2 (Thr1620/1623) Antibody detects endogenous MAP2 only when phosphorylated at threonines 1620/1623. This antibody does not cross-react with phosphorylated tau.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr1620/1623 of human MAP2. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites (1). Multiple MAP2 isoforms are expressed in neurons, including high molecular weight MAP2A and MAP2B (280 and 270 kDa), and low molecular weight MAP2C and MAP2D (70 and 75 kDa). Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. GSK-3 and p44/42 MAP kinase phosphorylate MAP2 at Ser136, Thr1620, and Thr1623 (2,3). Phosphorylation at Thr1620/1623 by GSK-3 inhibits MAP2 association with microtubules and microtubule stability (3).

Specifications