Cell Signaling Cav2.2/Cacna1b (E2q1y) Rabbit mAb

Name: Cell Signaling Cav2.2/Cacna1b (E2q1y) Rabbit mAb
SKU: CSIG-45339S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cav2.2/Cacna1b (E2q1y) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45339S

MFG.PART: 45339S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	190
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Cav2.2/CACNA1B (E2Q1Y) Rabbit mAb recognizes endogenous levels of total Cav2.2/CACNA1B protein.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1938 of mouse Cav2.2/CACNA1B protein.
Background	Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), or Cav2.2, is encoded by the CACNA1B gene (1,2). In the brain, Cav2.2 has been implicated in synaptic plasticity (3). Interestingly, altered Cav2.2 may contribute to some neurodegenerative diseases, such as Huntington’s disease (4).

Specifications