Cell Signaling Cleaved Caspase-7 (Asp198) (D6h1) Rabbit mAb (Alexa Fluor ® 647 Conjugate)

Name: Cell Signaling Cleaved Caspase-7 (Asp198) (D6h1) Rabbit mAb (Alexa Fluor ® 647 Conjugate)
SKU: CSIG-45330S
Price: 481.77 USD

List Price $481.77 Your Price $481.77

Cell Signaling Cleaved Caspase-7 (Asp198) (D6h1) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45330S

MFG.PART: 45330S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Cleaved Caspase-7 (Asp198) (D6H1) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of caspase-7 protein only when cleaved at Asp198.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp198 of human caspase-7 protein.
Background	Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5).

Specifications