Cell Signaling Tak1 Antibody

Name: Cell Signaling Tak1 Antibody
SKU: CSIG-4505S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Tak1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4505S

MFG.PART: 4505S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk B
Sensitivity	Endogenous
Molecular Weight (kDa)	78 to 82
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TAK1 Antibody detects endogenous levels of total TAK1 protein.
Species Reactivity	Human, Mouse, Rat, Monkey, Bovine
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of human TAK1. Antibodies are purified by protein A and peptide affinity chromatography.
Background	TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein and other cytokines including IL-1 (1,2). In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1 (3,4). Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation (5). Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase (NIK) (2).

Specifications