Cell Signaling Foxa1/Hnf3alpha (E7e8w) Rabbit mAb (Alexa Fluor 488 Conjugate)

Name: Cell Signaling Foxa1/Hnf3alpha (E7e8w) Rabbit mAb (Alexa Fluor 488 Conjugate)
SKU: CSIG-44957S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Foxa1/Hnf3alpha (E7e8w) Rabbit mAb (Alexa Fluor 488 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-44957S

MFG.PART: 44957S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:100 - 1:400}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	FoxA1/HNF3α (E7E8W) Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total FoxA1/HNF3α protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human FoxA1/HNF3α protein.
Background	Forkhead box protein A1 (FoxA1, HNF3α) is a transcription factor required for the development of endoderm-derived organs, such as liver, lung, and prostate (1). FoxA1 functions as a pioneer factor that is recruited primarily to the distant enhancers to change chromatin structure for transcription in a cell type-specific manner (2,3). The FoxA1 transcription factor is implicated in various diseases, playing a role in hormone-dependent disorders, such as breast and prostate cancers (4). The treatment of relapsing-remitting multiple sclerosis patients with IFN-β results in FoxA1-induced stimulation of a novel population of FoxA1(+) regulatory T cells, suggesting a possible immunosuppressive role for FoxA1 (5).

Specifications