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Cell Signaling Pxr (E4s1w) Rabbit mAb
List Price
$374.71
Your Price
$374.71
Cell Signaling Pxr (E4s1w) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-44646S
MFG.PART:
44646S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 45 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50, Chromatin IP: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | PXR (E4S1W) Rabbit mAb recognizes endogenous levels of total PXR protein. This antibody detects a 70 kDa band of unknown origin. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant human PXR protein. |
| Background | The pregnane X receptor (PXR) is part of the nuclear hormone receptor superfamily and is a master regulator of xenobiotic metabolism (1). PXR was initially described as being activated by pregnanes and inducing expression of the CYP3A family of steroid hydroxylases (2,3). Similar to PPAR and CAR nuclear receptors, PXR utilizes RXR as a heterodimeric partner and controls target hepatic enzyme genes to control liver metabolism in response to a wide variety of drugs (4). However, PXR is strikingly evolutionarily divergent, and the ligand-binding domain only shares around 75% identity across species. Compounds that readily activate human PXR, such as rifampicin, have little activity in rodents (5,6). In humans, in addition to naturally occurring steroids, PXR is activated by numerous xenobiotics, including anti-cancer drugs paclitaxel and tamoxifen, the HIV protease inhibitor ritonavir, and the anti-diabetic troglitazone (5,7-9). PXR has been implicated in numerous conditions, including inflammatory bowel disease, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD) (10-12). PXR plays a protective role in many tumor types and its expression is generally correlated with better prognosis (13-15). |
| SKU | CSIG-44646S |
|---|---|
| Featured | No |
| Supplier Part Number | 44646S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |