Cell Signaling Paip2a Antibody

Name: Cell Signaling Paip2a Antibody
SKU: CSIG-4422S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Paip2a Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4422S

MFG.PART: 4422S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	25
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Paip2A Antibody detects endogenous levels of total Paip2A protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human Paip2A. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The eukaryotic mRNA 3 poly(A) tail interacts with the 5 cap structure to regulate translation of mRNA transcripts (1). The eIF4G translation initiation factor associates with poly(A) binding protein (PABP) to circularize mRNA (1,2). Paip1 is a PABP interacting protein that binds eIF4A to stimulate translation (3). A second PABP binding protein, Paip2, inhibits translation by interfering with PABP function. Specifically, Paip2 reduces the affinity of PABP for poly(A) RNA and competes with Paip1 for PABP binding (1,2).

Specifications