Cell Signaling Mx2 (E7y8h) Rabbit mAb

Name: Cell Signaling Mx2 (E7y8h) Rabbit mAb
SKU: CSIG-43924S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Mx2 (E7y8h) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-43924S

MFG.PART: 43924S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	80
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MX2 (E7Y8H) Rabbit mAb recognizes endogenous levels of total MX2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn175 of human MX2 protein.
Background	Mx2 (MxB) is a dynamin-like GTPase that is highly upregulated by IFN-α and IFN-β and upregulated to a lesser extent by IFN-γ (1). It was identified as a potent cell-autonomous HIV restriction factor (2). Mx2 functions as an HIV restriction factor by blocking infection at the late post-entry step through prevention of nuclear accumulation and chromosomal integration (2). HIV restriction by Mx2 is dictated through the capsid region of the viral Gag protein (2).

Specifications