Cell Signaling Cd63 (D4i1x) Rabbit mAb (Ihc Specific) (Bsa And Azide Free)

Name: Cell Signaling Cd63 (D4i1x) Rabbit mAb (Ihc Specific) (Bsa And Azide Free)
SKU: CSIG-43890SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd63 (D4i1x) Rabbit mAb (Ihc Specific) (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-43890SF

MFG.PART: 43890SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #55051
Specificity/Sensitivity	CD63 (D4I1X) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD63 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant CD63 protein.
Background	CD63 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) (1-3). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin-enriched microdomains (TEMs) where they mediate a range of processes, including adhesion, motility, membrane organization, and signal transduction (3). CD63, like other tetraspanins, is enriched in exosomes (4). It is also a component of Weibel-Palade bodies found in endothelial cells (5). Research studies demonstrate several functions of CD63 in different cell types, including roles in mast cell degranulation, VEGF signaling in endothelial cells, recruitment of leukocytes to endothelial cells, and endosomal sorting during melanogenesis (6-9).

Specifications