Cell Signaling Cd14 (D7a2t) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Cd14 (D7a2t) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-43878SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Cd14 (D7a2t) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-43878SF

MFG.PART: 43878SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #75181.
Specificity/Sensitivity	CD14 (D7A2T) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD14 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro319 of human CD14 protein.
Background	CD14 is a leucine-rich repeat-containing pattern recognition receptor with expression largely restricted to the monocyte/macrophage cell lineage (1). Research studies have shown that CD14 is a bacterial lipopolysaccharide (LPS) binding glycoprotein, expressed as either a GPI-linked membrane protein or a soluble plasma protein (2). LPS induces an upregulation of GPI-linked CD14 expression, which facilitates TLR4 signaling and macrophage activation in response to bacterial infection (3-5).

Specifications