Cell Signaling Atp2a1/Serca1 (L24) Antibody

Name: Cell Signaling Atp2a1/Serca1 (L24) Antibody
SKU: CSIG-4219S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Atp2a1/Serca1 (L24) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4219S

MFG.PART: 4219S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ATP2A1/SERCA1 (L24) Antibody detects endogenous levels of total ATP2A1/SERCA1 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu24 of human ATP2A1/SERCA1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Sarcoplasmic and endoplasmic reticulum Ca2+ ATPases (SERCA) are members of a highly conserved family of Ca2+ pumps (1). SERCA pumps transport Ca2+ from the cytosol to the sarcoplasmic and endoplasmic reticulum lumen against a large concentration gradient (1). ATP2A1 (SERCA1) is a fast-twitch, skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (2). Research studies have shown that mutations in the ATP2A1 gene cause an autosomal recessive muscle disorder known as Brody myopathy, which is characterized by muscle cramping and impaired muscle relaxation associated with exercise (1-3).

Specifications