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Cell Signaling Mnx1/Hb9 (E3w8d) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Mnx1/Hb9 (E3w8d) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-41983S
MFG.PART:
41983S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 55 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | MNX1/HB9 (E3W8D) Rabbit mAb recognizes endogenous levels of total MNX1/HB9 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser231 of human MNX1/HB9 protein. |
| Background | Motor neuron and pancreas homeobox protein 1 (MNX1 or Homeobox protein HB9) is a homeobox transcription factor that has conserved functions in motor neuron differentiation and pancreas development. The mammalian central nervous system (CNS) is composed of specialized neurons, and the specification of neuronal identity in the CNS is determined early in development by spatially-specified expression of cell-intrinsic determinants, many of which are transcription factors (1). MNX1/HB9 is one such transcription factor. In response to developmental signals, MNX1/HB9 is expressed transiently to drive differentiation of ventral progenitor cells into somatic motor neurons (2,3). Mutations in the gene encoding human MNX1/HB9 are linked to Currarino syndrome, a developmental disease caused by dorsal-ventral patterning defects resulting in presacral tumors, sacral agenesis, and anorectal malformation in patients suffering from this disease (4,5). |
| SKU | CSIG-41983S |
|---|---|
| Featured | No |
| Supplier Part Number | 41983S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |