Cell Signaling Lat (E3u6j) Xp ® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Lat (E3u6j) Xp ® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-41708SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Lat (E3u6j) Xp ® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-41708SF

MFG.PART: 41708SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	36, 38
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #45533
Specificity/Sensitivity	LAT (E3U6J) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total LAT protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu88 of human LAT protein.
Background	LAT, a transmembrane adaptor protein expressed in T, NK, and mast cells, is an important mediator for T cell receptor (TCR) signaling (1). Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets (2,3). The phosphorylation of LAT at Tyr171 and Tyr220 enables the binding of Grb2, Gads/SLP-76, PLCγ1, and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways (1-4).

Specifications