Cell Signaling Ercc1 Isoform 3 (E6r3q) Rabbit mAb

Name: Cell Signaling Ercc1 Isoform 3 (E6r3q) Rabbit mAb
SKU: CSIG-40838S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Ercc1 Isoform 3 (E6r3q) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-40838S

MFG.PART: 40838S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	41
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ERCC1 Isoform 3 (E6R3Q) Rabbit mAb recognizes endogenous levels of total ERCC1 isoform 3 protein. This antibody does not cross-react with ERCC1 isoforms 1, 2, or 4.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg283 of human ERCC1 isoform 3 protein.
Background	DNA repair systems operate in all living cells to manage a variety of DNA lesions. Nucleotide excision repair (NER) is implemented in cases where bulky helix-distorting lesions occur, such as those brought about by UV and certain chemicals (1). Excision Repair Cross Complementing 1 (ERCC1) forms a complex with ERCC4/XPF, which acts as the 5’ endonuclease required to excise the lesion (2). ERCC1-XPF is also required for repair of DNA interstrand crosslinks (ICLs) (3) and involved in repair of double strand breaks (4). Research studies have shown that expression of ERCC1 is related to survival rate and response to chemotherapeutic drugs in several human cancers including non-small cell lung cancer (NSCLC) (5,6).

Specifications