Cell Signaling Klf5 (E5k6h) Rabbit mAb

Name: Cell Signaling Klf5 (E5k6h) Rabbit mAb
SKU: CSIG-40674S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Klf5 (E5k6h) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-40674S

MFG.PART: 40674S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	60
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:800 - 1:3200, Flow Cytometry (Fixed/Permeabilized): 1:100 - 1:400}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	KLF5 (E5K6H) Rabbit mAb recognizes endogenous levels of total KLF5 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu140 of human KLF5 protein.
Background	Kruppel-like factors (KLFs) are a family of zinc finger DNA-binding proteins that share homology to Kruppel transcription factor in Drosophila melanogaster (1). These transcription regulators play diverse roles in cell proliferation, differentiation, inflammation, and pluripotency (2). Various KLFs, including KLF5, are involved in cancer-related processes, such as epithelial-mesenchymal transition (EMT), invasion, and metastasis (3-6). In addition, studies show that KLF5 deficiency specific to renal collecting duct epithelial cells impairs cardiac stress adaptation response coordinated by the heart and kidney (7).

Specifications