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Cell Signaling Sars-Cov-2 Nsp2 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Sars-Cov-2 Nsp2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-40485S
MFG.PART:
40485S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | Vir |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 80 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SARS-CoV-2 Nsp2 Antibody recognizes endogenous levels of total SARS-CoV-2 Nsp2 protein in infected cells. |
| Species Reactivity | Virus |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of SARS-CoV-2 Nsp2 protein. Antibodies are purified by peptide affinity chromatography. |
| Background | The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is relatively large and encodes up to 29 open reading frames (ORFs). These include ORF1a and ORF1b (further processed into 16 non-structural proteins), nine accessory proteins, and four canonical structural proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N) (2). Nsp2 (non-structural protein 2) is derived from ORF1a and ORF1b (2). It is reported to interact with a protein involved in translational repression known as GIGYF2. GIGYF2 normally interacts with another translational repressor, 4EHP. These proteins together in a larger complex function to inhibit translation of mRNAs that may be defective during development. Upon infection with SARS-CoV-2, however, Nsp2 binds to GIGYF2 and exerts a stronger effect on host cell translation by 4EHP dependent and independent mechanisms, with inhibition of interferon translation being one of the notable effects (3). |
| SKU | CSIG-40485S |
|---|---|
| Featured | No |
| Supplier Part Number | 40485S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |