Cell Signaling Afp (C3) Mouse mAb

Name: Cell Signaling Afp (C3) Mouse mAb
SKU: CSIG-39971S
Price: 353.50 USD

List Price $353.50 Your Price $353.50

Cell Signaling Afp (C3) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-39971S

MFG.PART: 39971S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG2a
Application/Dilution	{IHC Leica Bond: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:100 - 1:400}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	AFP (C3) Mouse mAb recognizes endogenous levels of alpha-fetoprotein (AFP).
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with serum of a hepatoma patient that has affinity isolated human alpha-fetoprotein (AFP).
Background	Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells (1,2). The tumor suppressor gene p53 and β-catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma (3).

Specifications