Cell Signaling Ube2l3 Antibody

Name: Cell Signaling Ube2l3 Antibody
SKU: CSIG-3848S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Ube2l3 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3848S

MFG.PART: 3848S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	17
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	UBE2L3 Antibody detects endogenous levels of total UBE2L3 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys145 of human UBE2L3 protein. Antibodies are purified by peptide affinity chromatography.
Background	Protein ubiquitination requires the concerted action of the E1, E2, and E3 ubiquitin-conjugating enzymes. Ubiquitin is first activated through ATP-dependent formation of a thiol ester with ubiquitin-activating enzyme E1. The activated ubiquitin is then transferred to a thiol group of ubiquitin-carrier enzyme E2. The final step is the transfer of ubiquitin from E2 to an ε-amino group of the target protein lysine residue, which is mediated by ubiquitin-ligase enzyme E3 (1).UBCH7 (also called UBE2L3) is an 17 kDa ubiquitin-conjugating enzyme E2 (3). It can interact with different E3 ligase including E6-AP, SRC-1, c-Cbl, parkin and mediates regulation of a wide variety signaling pathways and is associated with diseases such as Parkinsons disease (4-7).

Specifications