Cell Signaling S5a/Psmd4 Antibody

Name: Cell Signaling S5a/Psmd4 Antibody
SKU: CSIG-3846S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling S5a/Psmd4 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3846S

MFG.PART: 3846S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	49
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	S5a/PSMD4 Antibody detects endogenous levels of total S5a/PSMD4 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly344 of human S5a/PSMD4 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	S5a (PSMD4) is a subunit of the 19S regulatory proteasome complex functioning in ubiquitinated-protein targeting and degradation (1). S5a contains two polyubiquitin binding motifs (UIM) that bind multiubiquitin chains by hydrophobic interaction (2,3). In addition to ubiquitin, the UIM of S5a shows high affinity to a ubiquitin-like domain present in many proteins. S5a binds to these types of proteins directly and mediates their targeting to the proteasome for degradation (4,5).

Specifications