Cell Signaling Lama1 (E4m5b) Rabbit mAb

Name: Cell Signaling Lama1 (E4m5b) Rabbit mAb
SKU: CSIG-37710S
Price: 374.71 USD

List Price $374.71 Your Price $374.71

Cell Signaling Lama1 (E4m5b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-37710S

MFG.PART: 37710S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	337
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LAMA1 (E4M5B) Rabbit mAb recognizes endogenous levels of total LAMA1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala2402 of human LAMA1 protein.
Background	Laminins are a family of proteins important for maintaining cellular basement membrane (BM) structure and function (1). Laminins exist as heterotrimers of alpha (LAMA), beta (LAMB), and gamma (LAMC) chains. Laminins are reported to be involved in multiple biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis (2). LAMA1 is thought to bind to cells via a high affinity receptor to mediate their attachment, migration, and organization of cells into tissues during embryonic development (2). Aberrant expression of LAMA1 is also associated with disease progression in patients with idiopathic pulmonary fibrosis (3).

Specifications