Cell Signaling Tapasin (E6p2z) Xp Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Tapasin (E6p2z) Xp Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-37427SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Tapasin (E6p2z) Xp Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-37427SF

MFG.PART: 37427SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	48
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #66382
Specificity/Sensitivity	Tapasin (E6P2Z) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total Tapasin. This antibody does not cross-react with Tapasin-R protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu60 of human Tapasin protein.
Background	TAP-associated glycoprotein (Tapasin/TAPBP) is a type-I transmembrane ER glycoprotein encoded by an MHC-linked gene. Tapasin plays a critical role in the MHC class I-restricted antigen processing and presentation pathway. Research studies have demonstrated that Tapasin is an IFNγ-inducible component of the TAP-1/2 peptide transporter complex and, within the ER lumen, facilitates the optimization of the peptide repertoire that is loaded onto MHC class I molecules (1-5). Downregulation of Tapasin and MHC class I expression has been observed in human tumors and serves as a prominent mechanism of tumor immune escape (6-9).

Specifications