Cell Signaling Gp130 Antibody

Name: Cell Signaling Gp130 Antibody
SKU: CSIG-3732S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Gp130 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3732S

MFG.PART: 3732S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	130
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	GP130 Antibody detects endogenous levels of total GP130 protein independent of phosphorylation.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human GP130. Antibodies are purified by protein A and peptide affinity chromatography.
Background	GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. These events lead to the activation of multiple signal-transduction pathways, such as the Stat, Ras-MAPK and PI3 kinase pathways, whose activation is controlled by distinct regions of GP130 (4-7).

Specifications