Cell Signaling Gapdh (14c10) Rabbit mAb (Hrp Conjugate)

Name: Cell Signaling Gapdh (14c10) Rabbit mAb (Hrp Conjugate)
SKU: CSIG-3683S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Gapdh (14c10) Rabbit mAb (Hrp Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3683S

MFG.PART: 3683S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk B Pg
Sensitivity	Endogenous
Molecular Weight (kDa)	37
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 136 mM NaCl, 2.6 mM KCI, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg/ml BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibodies.
Specificity/Sensitivity	GAPDH (14C10) Rabbit mAb (HRP Conjugate) detects endogenous levels of total GAPDH protein.
Species Reactivity	Human, Mouse, Rat, Monkey, Bovine, Pig
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide near the carboxy terminus of human GAPDH. The antibody is conjugated to the carbohydrate groups of horseradish peroxidase (HRP) via its amine groups.
Background	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the phosphorylation of glyceraldehyde-3-phosphate during glycolysis. Though differentially expressed from tissue to tissue (1), GAPDH is thought to be a constitutively expressed housekeeping protein. For this reason, GAPDH mRNA and protein levels are often measured as controls in experiments quantifying specific changes in expression of other targets. Recent work has elucidated roles for GAPDH in apoptosis (2), gene expression (3), and nuclear transport (4). GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimers diseases (4,5).

Specifications