Cell Signaling Plp1 (E9v1n) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Plp1 (E9v1n) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-36593SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Plp1 (E9v1n) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-36593SF

MFG.PART: 36593SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	20-30
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #28702
Specificity/Sensitivity	PLP1 (E9V1N) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total PLP1 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PLP1 protein.
Background	Myelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating the axonal growth (1). DM20 is the result of the alternative splicing of the plp1 gene, which is linked to oligodendrocyte differentiation and survival. The imbalance of PLP1/DM20 is linked to Pelizaeus-Merzbacher disease (2,3), including mitochondrial damage (4). In addition, PLP1, but not DM20, can enter the mitochondria and participate in the metabolism of cells (5).

Specifications